Prothrombin Complex Concentrates in Pediatric Cardiac Surgery: The Current State and the Future
نویسندگان
چکیده
منابع مشابه
Prothrombin complex concentrates in warfarin anticoagulation reversal
Anticoagulation is very effective for primary and secondary prevention of thromboembolic events. However, questions persist about the risks and management of over-anticoagulation. The annual incidence of major bleeding in trials and cohort studies has been reported to be between 1.1% and 2.3% in patients treated with warfarin to achieve an international normalized ratio (INR) of 2.0 to 3.0. The...
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We would treat with 4-factor PCCs because otherwise—with an INR of 1.9—there is a high risk of further expansion of an already large ICH. Without reversal of the anticoagulant effects of warfarin, the patient’s life is at stake. At age 65 years, he has a reasonable chance to recover from a right-sided ICH if treated early and aggressively. In our eyes, early withdrawal of care is not an option!...
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Prothrombin complex concentrates (PCCs) contain vitamin K-dependent clotting factors (II, VII, IX, and X) and are marketed as 3 or 4 factor-PCC formulations depending on the concentrations of factor VII. PCCs rapidly restore deficient coagulation factor concentrations to achieve hemostasis, but like with all procoagulants, the effect is balanced against thromboembolic risk. The latter is depend...
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In a recent paper White et al.’ reported that the thrombogenic properties of prothrombin complex concentrates (PCC) are due to the presence of factors IXa and Xa. The presence of these activated factors, however, was detected indirectly by applying different inhibitors, e.g., a specific seryl reagent, phenylmethylsulfonyl fluoride (PMSF). They concluded that the effect of PMSF is due to the ina...
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Background and Objective: The present study aimed to assess the role of magnesium sulfate (MgSO4) sup-plementation after cardiac surgery in pediatric patients, evaluating the incidence of cardiac complications, such as arrhythmia. Methods: In this study, 105 children scheduled for elective cardiac surgery were randomly divided into 3 groups. The first group, as the placebo group, received sali...
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ژورنال
عنوان ژورنال: The Annals of Thoracic Surgery
سال: 2017
ISSN: 0003-4975
DOI: 10.1016/j.athoracsur.2017.04.009